Needle-free skin patch vaccination method for anthrax.
نویسندگان
چکیده
Three immunizations of mice with recombinant protective antigen (rPA) by transcutaneous immunization (TCI) induced long-term neutralizing antibody titers that were superior to those obtained with aluminum-adsorbed rPA. In addition, rPA alone exhibited adjuvant activity for TCI. Forty-six weeks after completion of TCI, 100% protection was observed against lethal anthrax challenge.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 72 2 شماره
صفحات -
تاریخ انتشار 2004